Not OP, but I think this means that it isn't a mainstream enough idea to get traction, and that it might be political suicide for an elected official to suggest it, not that society is ill-equipped to handle it if it did happen.
I share this position. I think it's a good idea to legalize most drugs, but I think actively working toward legalizing drugs other than marijuana today would not get much in the way of results.
The drug war has been a complete and utter failure from the viewpoint of society (those who have profited may disagree, but I hope we can agree their views can be ignored). IT has ruined lives, brought misery and suffering to many, all but destroyed some countries, helped wars continue long after they would have otherwise, unfairly targeted minorities.
And for what gains? None, absolutely nothing. Drugs are cheaper, purer and more available than ever. That is all the billions if not trillions of $ has achieved.
We should absolutely change how we deal with drugs and addition, but I'm not convinced that straight legalizing things like meth is the right approach, either.
I actually hope to see the day when cannabis is more legal than tobacco cigarettes. When cannabis starts piling up the corpses, it can then be made as legal.
Whereas legalizing it would mean that I'm free to manufacture meth and heroin and market it, and sell it to others; I would still have an incentive to use some drugs' inherently and biologically addictive nature to profit myself at the expense of others.
I specifically say "inherently and biologically" because many things are addictive to a degree - alcohol, tobacco, video games, in-game purchases, gambling - and any of them can ruin some person's life. But they don't appear to be as universally addictive as, say, heroin or meth, which can have terrible repercussions even if you stop using them. It's a difference of degree, but it's a significant one, and I want to head off at the pass any argument that selling meth to my neighbors is no different than selling them sugary soda or cookie-clicker clones.
And you can't tax them too highly, either, or those black markets spring right back into existence. See moonshining or cigarette smuggling for examples. A 25% excise tax at the point of sale to the consumer is probably the highest you can go. Taxation is, after all, one of the ways in which prohibition was backdoored into existence, and the amount of the tax is the maximum possible profit margin for someone whose sole business is evading the tax.
That leaves open the question of how you keep the most dangerous drugs--generally the opioids--from ruining people. That's really a moot point until the end of prohibition seems imminent. If certain people won't consider any other option, it's useless to throw one out there for discussion.
If society isn't ready for that, why are you for it?
(fwiw, I'm with you on marijuana, and hope to see the day when it's as legal as cigarettes - but people have been optimistic about marijuana for decades :/)