Sure (if true), but that's not the point, because driving more doesn't increase mileage. Why does driving more make you prefer less efficient cars? What do you get back from it?

Sorry I forgot to finish the point for 1.

A larger car (more space, inertia and soundproofing) with a bigger engine (lower rpm therefore less noise) with more cylinders (less vibration) is more comfortable and wears you down less. And I loved my wife's no frills stick-shift Versa (4000 rpm at 80 mph really got annoying though)

As to American's driving large distances, based on my personal experience, there's no comparison. American cities are further apart, families are more scattered, families are larger. Don't forget that in many ways America is actually two societies in one. One America lives in places largely undistinguishable from Europe. The other has 90 mile one way commute (a colleague. Mine is only 17).

Driving 500 kilometers without stopping is terribly dangerous for yourself and the people around you. Please be considerate.

It's a matter of practice. 500 km is 312.5 miles. At 60 mph, this is about 5 hours of driving. You can definitely handle 5 hours of driving at one shot. Start at a time when you don't expect to feel sleepy for the next 5 hours and you'll be set.

No, it isn't. It's the difference between driving in the EU and driving in N America.

I can't think of any 500 km route in Europe that wouldn't destroy me. And a little engine screaming for dear life wouldn't help

no it's not. that's 4 hours of highway driving. waking up and starting a drive at 6am and driving until 10am is not any more dangerous than normal short trips and in fact is probably safer since you aren't dealing with intersections.