Hard to say. Since you're a finger in the Hand, I guess the palm would tell you to fold.

..when in comes the EU, who have successfully penalized and stared down Facebook, Intel, Apple and Microsoft. And which is either the biggest (until the Brits have officially left) or the third biggest economy in the world. You can't simply ignore them, even as a company of Google or Apple's size.

This is mainly a covert trade war with the US due to taxes. The US has also succesfully penalized VW.

The brits may not leave, the english will but the scots may leave the UK to stay in the EU which may domino effect northern ireland to leave too and last I check London was thinking about segregating to become a city state to stay in the EU. Also a few islands are expected to be offered to join Spain the minute brexit is acted.

EU rules prevents EU members from dealing directly with a part of a EU member so no negociation are possible with any member of the UK until brexit.

Let's see if the scottish referendum happens...

The EU had two different pending antitrust sanctions for Google, one around shopping ads and one around Android. Then nothing more about it since about mid 2016. Are those still pending?