All good advice but, alas, it doesn't work if you are the one with the thimble bladder. Which correlates with age and various medical issues such as hypertension for which diuretics are prescribed. (I speak from experience.)
In that case, you really want an aisle seat within two rows of a toilet block, so you can stumble to the loo and back without having to fully wake up.
That's a win-win then :)
I'll take a window seat if available, but it infuriates me that the arm rest between the window seat and the sidewall of the airplane DOES NOT MOVE. Space is so precious on airplanes that I can pay an extra $50 for 2 more inches, but I can't use the 4-6 inches between me and a wall? (I wish I had a multi-tool handy.)
I always take the aisle because (i) you have the freedom to walk about, go to the restroom, etc. anytime you like and (ii) you can steal some space by jutting your knees slightly to the aisle.
For me, it's usually just a glass or two of red wine at the airport bar before takeoff, and maybe another on the plane. I'm not much of one for taking off my shoes or getting half undressed on the plane.
I also make it a habit to generally not talk to any seatmates or introduce myself. Leads to the possibility of someone thinking it's an open invitation to talk/pester you the entire flight.