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A comment on Modafinil-Induced Changes in Functional Connectivity of Healthy Elderly Subjects. Parent comment

Re:Modafinil-Induced Changes in Functional Connectivity of H... by always_good on Saturday April 08, 2017 @07:44PM (#14069694)
Modafinil is instant release, so it's hard to take therapeutically. Tolerance builds too quickly.

I'd be interested in an slow release format since the drug can be bought over the counter where I live.

Though it's not even in the same ballpark as amphetamine. I fly back to the States just to re-up my Vyvanse prescription.

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Re:Modafinil-Induced Changes in Functional Connectivity of H... by colordrops on Sunday April 09, 2017 @02:41AM (#14070835)
Where do you live? For what condition is it sold over the counter?
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Re:Modafinil-Induced Changes in Functional Connectivity of H... by ghiar on Sunday April 09, 2017 @04:57AM (#14071223)
Primarily narcolepsy.
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Re:Modafinil-Induced Changes in Functional Connectivity of H... by WalterSear on Saturday April 08, 2017 @08:55PM (#14069903)
The tolerance builds up quickly, regardless.
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Re:Modafinil-Induced Changes in Functional Connectivity of H... by always_good on Saturday April 08, 2017 @10:19PM (#14070128)
Well, I said "too quickly". You have to address tolerance for all drugs in this space, but some are ridiculous.

I couldn't even feel the Modafinil on day 3 without taking 5x the dose. That's a bit silly.

Instant release amphetamine ends up being more like a party drug for the same reason, though less extreme.

Compare that to a slow release amphetamine (prodrug) like Vyvanse where most people can hit a 2+ week cycle of constant use, or an indefinite cycle by only dosing a fraction of the week.

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Re:Modafinil-Induced Changes in Functional Connectivity of H... by krob on Sunday April 09, 2017 @08:59PM (#14075248)
if you follow what other people do when using modafinil, they sometimes mix coffee w/ small amounts of modafinil which improves it's overall offectiveness. I personally prefer the mental zing of Loose Leaf Black Tea.
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Re:Modafinil-Induced Changes in Functional Connectivity of H... by WalterSear on Monday April 10, 2017 @01:52PM (#14080909)
This won't help with tolerance.
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