As far as safety, the input transformer is -boosting- your 120vac to 400vac-500vac :) So it's not protecting you from anything :D
My topology could be arguably safer... First, 120vac->24vdc via switching PSU. This actually provides the isolation you refer to. Then the 24vdc is split, part of it is switched down to 6.3vdc for the tube heaters and the other part is put through a ZVS boost circuit 24vdc->376vdc. Even with the double conversion, my efficiency is about 78%! I have complete isolation from AC via the first power supply. I bond my negatives to earth for safety. The best part is, this amplifier is dead quiet because the switching noise is very easy to filter.
Among players, there's a lot of cork sniffing and brand worship unfortunately. I feel like "weight" is something tangible that anyone could measure: Saving 5-6lbs, running cooler, and being more portable are things that would appeal to a lot of people.
Here's a hint: Let's say we're both right, hypothetically - no other product does this! However, since there's nothing about the design that's intrinsically yours (IE - it's combining a few undergraduate EE course projects at once) somebody else will go make it in China as soon as you demonstrate that there's a market.
Unless, of course, you really have discovered some new area of AUDIO CIRCUIT DESIGN (just about the simplest shit there is, circuit-design wise). Not...very...likely...