I've been working with TypeScript a lot over the past year and prefer it to some other languages now(like Python). I would still probably prefer C# and dotnet; all the way if it ran in the browser.

* .Net is faster * ASP.NET Core is faster * .Net uses thread pools for task scheduling; parallelism * Run time type information * An mostly complete task(async/await) based stdlib(node hasn't even started on this to my knowledge) * Linq -> fantastic * Entity Framework -> not without some quirks, but fantastic * Roslyn; feeding dev-time code generation back into your compiler/tools allows for some really cool IDE aware tooling. * Cool JIT/IL stuff like Jil * More number types than "number" * etc