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Re:Scientists want to create ‘red teams’ to challenge climat... by epistasis on Wednesday March 29, 2017 @04:30PM (#13990273)
Yes, the differences are massive. There's a huge signature of "bulky adduct" repair in smokers' samples. This looks different than, say, UV damage. See, for example, signature #4 from this paper:

http://www.nature.com/nature/journal/v500/n7463/full/nature1...

Re:Scientists want to create ‘red teams’ to challenge climat... by hutzlibu on Wednesday March 29, 2017 @04:56PM (#13990505)
Thanks, thats interesting
Re:Scientists want to create ‘red teams’ to challenge climat... by nonbel on Wednesday March 29, 2017 @05:57PM (#13990986)
>"All cancers are caused by somatic mutations"

Its strange that epistasis cites that paper so freely since he has expressed skepticism about this idea in the past. In fact I may have discussed that exact paper with him awhile back. The layperson probably wouldn't realize it but this is a very hubristic first sentence, almost purposefully offensive.