I used to (and still occasionally) suffer from staring out into the stars at night and realizing how insignificant I am. We should all be like Zaphod, eh?
Just remind yourself that life in an absurd universe is pointless, so there's no need to achieve anything beyond having a nice snack and a beer this evening.
To be honest, the thing that's most improved my happiness is exercise. It wasn't that long ago I (re)discovered the joy that you can observe on the faces of small children when they run for the sake of feeling their muscles move.
And yes, exercise is excellent for nearly every malady. (See Plato for specifics.)
One has been completely inactive as far as I can tell, but the sense of "repression" has always been strong. I have no idea what the root of this is, but mutual friends have all commented on it at some point.
As for the remainder, it is best to draw the curtain of modesty over the scene.
One is a genius of memory. He memorized the entire Norton Anthology of Poetry when he was a child. (I'm not even kidding.) In college we all played a game where we would give him the first line of a poem. He would then supply the title of the poem, the author, the year it was published, and generally the rest of the poem, or at least the rest of the first verse. He's a college professor. You've never heard of him, but his students invariably love him. He changes people one at a time.
There are others in this group who are very accomplished in publishing, acting, comedy. I also know a guy whose name is associated with the creation ("discovery") of several elements. (I suspect he glows in the dark from all the radiation he has absorbed, but I haven't actually confirmed that.) Tough crowd if you're in a mood to compare yourself.