How the Brain Dumps Its Trash (2016) [video]

Re:How the Brain Dumps Its Trash (2016) [video] by pizza on Sunday March 05, 2017 @12:15PM (#13797018)

No. Drug-breakdown processes have long been studied, whereas this is something new. Drugs like caffeine are removed by metabolic enzymes in multiple stages - e.g. here is a flowchart of caffeine's metabolic pathway https://s3.pgkb.org/pathway/PA165884757.png?versionId=XtszC7...

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Re:How the Brain Dumps Its Trash (2016) [video] by semi-extrinsic on Sunday March 05, 2017 @12:48PM (#13797238)

But that's not how caffeine is removed from the brain - that entire flowchart says "liver cell". Is one to understand that as the liver cleans blood of caffeine, and this low-caffeine blood eventually goes up to the brain, caffeine diffuses somehow (across the blood/brain barrier) into the bloodstream and is then carried to the liver?

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Re:How the Brain Dumps Its Trash (2016) [video] by pizza on Sunday March 05, 2017 @01:38PM (#13797633)

Essentially, to my knowledge.. of relevance:

https://en.wikipedia.org/wiki/Distribution_(pharmacology)

https://en.wikipedia.org/wiki/Pharmacokinetics

https://en.wikipedia.org/wiki/ADME

https://en.wikipedia.org/wiki/Compartment_(pharmacokinetics)

https://en.wikipedia.org/wiki/Clearance_(pharmacology)

https://en.wikipedia.org/wiki/Plasma_protein_binding

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