I like that Safari supports content-blocking extensions that it guarantees can't read or transmit content from webpages. Makes me feel safer about running them, rather than relying on goodwill. I'm not sure if Chrome has a similar feature.

I find Chrome trashes my battery, and for some reason will never quit reliably and requires force-quitting. I've also never figured out how to start Chrome with an empty blank screen, which I feel should be simple enough...

However, I do still use Chrome sometimes because some websites simply work better with it and it has integrated Flash support (which means I don't need to install Flash globally in my system).

I am very happy using wipr.safariextz over even uBlock Origin on FF. It just works.

I use Chrome only for a) google docs b) flash/pdf c) news sites that block me due to content-blocking.