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Re:Rax – A universal React-compatible render engine by bjacobel on Friday January 13, 2017 @08:01AM (#13390461)
Preact doesn't offer a full synthetic events system so handling e.g. touch events cross-browser may cause you a little more headache than it would in React.

But I'm currently using Preact (server-rendered) for my personal site and loving the speed and byte size.

Re:Rax – A universal React-compatible render engine by developit on Friday January 13, 2017 @10:08AM (#13391335)
FWIW, there is actually no code in React to normalize touch events between browsers. For touch events react and preact are basically the same (aside from React creating a lot of pooled objects for their synthetic event system, and preact not using delegation).