Adderall and Vyvanse are basically the same thing, it's just that Vyvanse is the prodrug form that can't be insufflated for quicker delivery. It'll be the same as it is orally.

Methylphenidate is a different beast altogether and not neurotoxic like the amphetamines are even though in therapeutic doses amphetamines are also extremely safe. The difference is that amphetamines are both dopamine reuptake inhibitors and dopaminergic releasing agents while methylphenidate only inhibits dopamine reuptake alongside its effect as a CNS stimulant.