I went on a bike tour where I rode for 13+hrs a day for a month. At the end of the day the only thing sore was my muscles.
I weigh almost 300lbs.
A recumbent bike is a complete life changing, world altering, paradigm shifting, bundle of awesome. I beg you to look into it, or send me a PM if you have any questions.
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I am "eyeball-level" with most cars/sedans. I am lower then most mini-vans.
As a general rule-of-thumb 75% of vehicles give me more room then they do when I ride a traditional bike. I would say that the majority of cars give me "half the lane" (which would mean that they pull over far enough that their right-side tires are in the left-side wheel track).
BUT, I still get atleast 1 vehicle a day that drives too close. In some parts of town this is more likely to happen then others, it also depends on road/traffic/other conditions too. When I am areas or during times-of-the-day where it is not as safe for me, I 'Take the Lane' and don't let cars try to drive beside me.
In my city I can either take road (12km route) or dedicated bike paths for most of the trip (20km route). I always prefer the bike paths.
I say that to say this; running is way better for my back than cycling. My left leg, mostly my foot, still haven't completely recovered from the nerve impingement, but I am running 30 to 40 miles a week with no problems (lots of trail running too, check my Strava :) )
I can't cycle like I used to on any "normal" bicycles. This position, bent at 90 degrees or more, that one is required to sit while cycling is actually pretty terrible for the lower back. Also, being male and being part of a large male dominated industry - firefighting, I see lots of male cancers. That is, testicular and prostate cancers. My department is participating in a massive testicular and prostate study; We are being asked to change our chonies often and wash hands before going to the bathroom as the scrotum is a sponge for anything it touches... smashing that region when cycling for extended periods of time seems like a bad idea (and it hurts).