Re:Smoking “causes hundreds of DNA changes”
by nonbel on Friday November 04, 2016 @10:37AM
(#12872859)
Of course, that seems to be exactly what is going on:
>"These considerations of mechanism suggest that at chronic doses close to the toxic dose, any chemical, whether synthetic or natural, and whether genotoxic or nongenotoxic, is a likely rodent and human carcinogen. Not all chemicals would be expected to be carcinogens at high doses; the MTD may not be reached (101) or the chemical may be toxic without causing cell killing or mitogenesis."
>"These considerations of mechanism suggest that at chronic doses close to the toxic dose, any chemical, whether synthetic or natural, and whether genotoxic or nongenotoxic, is a likely rodent and human carcinogen. Not all chemicals would be expected to be carcinogens at high doses; the MTD may not be reached (101) or the chemical may be toxic without causing cell killing or mitogenesis."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC54830/