This might just be an isolated incident, but it shakes my confidence in the utility of the six-speed suite. I actually do want to know whether there's a speed difference between const { a } = obj vs const a = obj.a, and the suite does not test that. (Worse, it kind of claims that it does, but reports something else instead.)
If 'let' prevented inlining, I would want to know, but I'd have to look very closely at the six-speed benchmarks to figure out whether it's detecting that. And the range of subtle reasons for deoptimization is vast, so despite working on a JS engine myself, I doubt I'd be able to tell whether a given microbenchmark is meaningful or not.
(Note that the Firefox devtools does have a "Show JIT Optimizations" that can tell you why things aren't getting optimized, but it's incredibly cryptic, undocumented, and scaremongering.)
The best suite I've seen is https://kpdecker.github.io/six-speed/ which measures node and the various modern browsers which Sauce Labs supports and appears to be run semi-regularly.