>Here we report the results from quantitative MRI and neuropsychological testing in ten patients with cognitive decline, nine ApoE4+ (five homozygous and four heterozygous) and one ApoE4-, who were treated with the MEND protocol for 5-24 months.

The number of patients studied is too few, i.e. is grossly underpowered statistically, and the results do not allow any general conclusion to be drawn.

Fascinating, thanks for the links. These findings might be preliminary, as this criticism of the claims lays out the case that it might be premature to make such assertions this early.

https://www.sciencebasedmedicine.org/mend-protocol-for-alzhe...

The commercialization of the MEND protocol might have run into some partnership issues between the original researcher and the first company he worked with dispensing the treatment:

http://www.prnewswire.com/news-releases/dr-dale-bredesen-ann...

Here is a more layman-friendly description of the MEND protocol.

http://bottomlineinc.com/alzheimers-symptoms-reversed/

The reviews of this work conclude that it is dubious, example: https://www.sciencebasedmedicine.org/mend-protocol-for-alzhe...