Do you have the right to use strong encryption? If you can fit it into a right the framers would have recognized based on English law and tradition (probably free speech), then yes. If not, then no. The 10th amendment has nothing to say about that.
Fundamentally, the Constitution is not really about "rights." The Bill of Rights was added to appease those who were worried the central government would impinge on the traditional rights of Englishmen. But the real purpose of the exercise was to create a powerful, but democratic, central government that had the authority to do the things that needed to be done.
To be precise, the 10th amendment is a nullity if you already accept that the federal government is one of enumerated powers. At the time of the founding, that was a novel concept and it probably made some people feel better to have it stated explicitly. But today that's taken as a given. The debate is never over if the government has powers not enumerated, but whether a particular action falls within the scope of an enumerated power. And the 10th amendment tells you nothing about the scope of the enumerated powers.
On the one side you have the "But the Framers didn't have machine-guns, or CRISPR." On the other side you have people who would ask "So I don't actually have a right to use strong encryption? I don't have a right to build a rocket? I don't have any rights that were not imagined by the Framers? All new inventions have to be allowed before they can be used?"
Otherwise anything could be "necessary and proper."
So, let's have a hypothetical about something really fundamental: If I could CRISPRize negligible senescence, or superintelligence, do I have the right to do it?