The only thing that it really chokes and dies on is if I try to open a mix of C#, SQL, JS and HTML files at the same time. I'm not totally sure what it is doing or analyzing, but the memory usage jumps up to somewhere north of 2GB with a lot of disk thrashing, when I might have 200 kb of text files open. JavaScript intellisense seems to be the most likely culprit, to the point that I have gotten in the habit of doing all front-end editing work in WebStorm, and reserving VS for the backend code, which is a much happier experience.

This is on Windows 10, with a solution of about 15-25 projects. At one point it was close to 100K LOC, but that was before we went in with fire and sword to remove some terrible, terrible amounts of redundancy, so it's considerably less now.

I have also similar issues with VS2015.

It's painfully slow without any extensions installed, even with a relatively small 200 kloc C++ project.

Just switching between source code tabs takes about 2 seconds.

In my experience with vs2015 and Windows 10, Windows defender can cause big slow downs.

Try to add scan exceptions for devenv.exe and your development folders.

Your mileage may vary.

Im using it on windows server 2008r2 it works fine. The only thing that slows things down for me is opening a sql file, so I never do that.