But first, we need to understand the cell. For this we believe we need not only statistical learning, but also formal methods. See e.g. a slightly dated but brilliant paper from Luca Cardelli:

http://lucacardelli.name/Papers/Abstract%20Machines%20of%20S...

Zuckerberg should give you all his money.

Constant blood surveillance is already a fact--that is, perhaps we don't need more blood. Instead, we just do the immune sequencing on the stream that's already available. Spread out over the whole population, that's a lot of information. Firmware updates, if necessary, could be handled on an as-needed basis, or more generally like flu vaccines.

I'm not sure how the giant cube-shaped space ships will be handled--that's definitely a hurdle to consider.

Fixing the existing body is nice, but you're forever limited by what nature intended, and what it intended is just not very good.