I'm not a fan of Pandemic, but Pandemic Legacy is a fantastic change on this monotony. 15-18 games spread over longer period, where the rules (and the board) change as you play. Not for everyone, especially if you don't manage to get a semi-regular group to play, but we had a blast with the story-based gameplay.

https://boardgamegeek.com/boardgame/161936/pandemic-legacy-s...