Some of it might come from creepy movies or sad history of psychiatric institutions, which is unfortunate.

However, recently there was an unexpected result regarding schizophrenia suggesting it might be just a result of a genetic bug of extensive deletion of redundant neurons in the brain, a bio-computational problem when you look at it with the eyes of a hacker. If confirmed, this would invalidate a lot of previous research and force the whole field to take a bit different, algorithmic view on many issues.