It might make sense one day when when processor improvements level off even more than they already have.
On the other hand, it might be a neat idea to OEM a high end x86 system and sell it as a purpose built "mathematica machine," with Mathematica pre-installed, the best supported GPU, optimal RAM and CPU, etc.
Besides the CPU there is another, even more important, difference. Lisp systems were all the way down to the metal developed in Lisp. Mathematica is largely written in C++ (runtime, environment, ...) and runs on top of a conventional OS (Windows, OSX, Linux, ...).
I think the take away was learned when every generation of the x86 would be a significant leap in performance. As you say in paragraph 3, things might change with the leveling off of improvements.
> On the other hand, it might be a neat idea to OEM a high end x86 system and sell it as a purpose built "mathematica machine," with Mathematica pre-installed, the best supported GPU, optimal RAM and CPU, etc.
I've been pitched by salesmen that their machine is a killer machine for Mathematica. We don't use it here, so I was not really into it as much as buying the sealed medical computers for the carpentry people.
It's called Macsyma and existed long before Mathematica. Macsyma was ported to Lisp Machines, in fact Lisp Machines exist partly because of Macsyma. It was one of the early Lisp applications which needed better and dedicated (not timeshared) hardware.