The biggest problem will be dealing with their influence over state legislatures. Tesla already upset dealerships; the idea of someone like Apple (with their capital on hand, experience, and influence at the federal level) following in Tesla's footsteps will be enough to terrify dealerships into some pretty heavy-handed action.
As for the supply chains, there are a lot of differences between the supply chain for consumer electronics manufacturing and automobile parts, but Apple's experience is still intensely relevant. I think it's likely that they'll have a lot of successes in dealing with it, despite those differences.
Supply chain -> Assembly (manufacturing) -> sales (Dealership)
Tesla's attacking laws that say that all new autos have to be sold by dealers. That's quite different, and only a few states have such laws.