Recently a paper went by on how something like 90% of medical studies are not able to be replicated in follow-up studies. If you really understand science qua science (as opposed to science-as-religion-substitute), you should understand this isn't a minor interesting tidbit to be discarded, this is a dagger to the heart of the field. Other fields seem to be having similar problems.

I reiterate, science is still the best we've got and I don't anticipate a replacement. But the evidence strongly suggests that the quality of the real science being done is a lot lower than it may appear at first glance, or what some people would have you believe.