Just because something is really hard does not mean it is not of much interest theoretically or practically. Everything that is meaningful in human endeavor has been "really hard."
I think that it is actually really important to study and understand personality change. Frankly, a lot of people have negative, (self)destructive personalities, and they would be much better served with positive, constructive personalities. Maybe if we understand how people change, we could come up with a consistent, efficient method to help those people, rather than shrugging and saying "haters gonna hate."
I view this as a failure of modern statistically driven social sciences. Just because it happens to only a few in a hundred people, doesn't mean it's an anomalous behaviour. People are messy. When put in differing circumstances, people show amazing plasticity in their behaviour. And controlling for all those social and biological pressures is very hard to do.
Researchers are also aware that personality changes population-wise with age, and also that individuals also experience personality changes -- but generally not in a medically interesting way in the sense of a reliable and precise intervention to effect positive changes.
I'm also reminded of studies on the transferability of personality traits with adopted children (no significant correlation! amazing! same correlation with biological parents compared to those children raised by their biological parents), or reared-apart monozygotic twin studies, or reared-apart dizygotic twin studies, and so on. The collective portrait of many data points suggests a set of stable biological factors to personality, as opposed to personal experience.
Of course, if you took a decent sized plow and cut a channel through the landscape early enough, you could direct the development of the river to exactly where you wanted it. If you wait too long, redirecting the river becomes a major engineering task; involved, but still entirely doable.
Shouldn't the unique experience of an entirely different household have some effect on personality?
This pattern is observed all the time for tastes. We have genetically predetermined preferences, but overwhelmingly what we end up liking is the result of social conditioning.
It seems to me that certain aspects of a person are very malleable, taste being one of them. But many other things apparently are not (IQ, or various other measures of 'intelligence', if I recall correctly).
From my experience in the social sciences, we tend to underestimate the role of genetics more often than not.
On the other hand, when a child displays an initial dislike for like Taylor Swift, her friends might say "you're crazy, Taylor Swift is awesome."
It's all just neural networks being reinforced or inhibited, the primary contribution of genetics is the default state of the network. In the case "fixed" personality characteristics, our culture is to reinforce the default networks, while for things we view as mutable, we have no qualms about training away default behavior.
And I suspect that the genetics does also set a limit as to how far one can bend, too. This too, will vary between persons.
"Entrepreneurship doesn't happen. The data are very clear on this. Most people who start businesses fail."
I could go on at length about my personal experience (which is quite dramatic) but since I enjoy my privacy I'll just pass along a funny story about massive personality change induced by brain injury: http://www.dailymail.co.uk/health/article-2130900/Chris-Birc...