The big problem with noscript, and this has already been mentioned on here, is that it requires a certain level of experience with the web to operate.

You almost have to be an experienced webdev to recognize which domains are necessary and which aren't.

But this is also why I emphasize that you can freely use the global whitelisting option and still be much safer than without noscript. Simply because the sites that will get you are often the sites that open unexpectedly. Unknown domains that you did not request.