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A comment on The genomic era arrives, and this time is probably real. Parent comment

Re:The genomic era arrives, and this time is probably real by swalsh on Monday May 09, 2016 @09:32AM (#11659666)
The article kind of says that though, the very beginning of the article explains how it was assumed that after we sequenced a genome, we'd make fast progress. However what's actually starting to make a difference is the sequencing of greater number of genomes (more data), and the improvement of our filtering (identification and algorithms). Basically, the big difference is a lot of hardwork, and refinement. There's not actually any mention of a single breakthrough discovery.
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Re:The genomic era arrives, and this time is probably real by nextos on Monday May 09, 2016 @01:04PM (#11661344)
I think it's not only about genomes.

Actually, cells have a lot of state. See [1] for a basic, slightly old, CS-biased explanation.

That's how a single genome yields an incredibly varied repertoire of cell types. We need to work a lot on understanding those epigenomes to then get a chance to pinpoint genetic causes of disease.

[1] http://ds9a.nl/amazing-dna/

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Re:The genomic era arrives, and this time is probably real by kens on Monday May 09, 2016 @03:32PM (#11662477)
Yes, cell state is really important. My view is that nobody is looking at the big picture of state - cells store state in many different ways, with time periods of milliseconds to years. It's probably my CS background, but I think figuring out all the relevant state of a cell is important and neglected. Epigenetics is a part of this, but not enough.
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Re:The genomic era arrives, and this time is probably real by haihaibye on Tuesday May 10, 2016 @07:25PM (#11671490)
RNAseq, the measure of abundance of transcribed genes at a particular cell state is one of the most common assays done with next gen sequencing. That's the big one then of course there is also miRs, transcription factors, methylation, histone marks, chromatin conformation capture.

As someone with a CS background who has worked almost 5 years in bioinformatics, one thing to realise is if you think something obvious is not done, either you're missing the right search term on pubmed or there's some horrible lab issue that makes it really hard (and we need a new assay/tech)

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Re:The genomic era arrives, and this time is probably real by ThePaco on Monday May 09, 2016 @09:40AM (#11659729)
I think I get where the rant is coming from though. Even though the article isn't talking about a single discovery, it's more the idea that the world will turn one day and it will suddenly be the age of
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Re:The genomic era arrives, and this time is probably real by azernik on Monday May 09, 2016 @01:32PM (#11661545)
I feel like the "And this time it's probably real" is kind of a tongue-in-cheek reference to that sensationalism.
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Re:The genomic era arrives, and this time is probably real by api on Monday May 09, 2016 @11:12AM (#11660392)
It's just a click bait title really.
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