Re:The genomic era arrives, and this time is probably real
by kens on Monday May 09, 2016 @03:32PM
(#11662477)
Yes, cell state is really important. My view is that nobody is looking at the big picture of state - cells store state in many different ways, with time periods of milliseconds to years. It's probably my CS background, but I think figuring out all the relevant state of a cell is important and neglected. Epigenetics is a part of this, but not enough.
[ Parent
| on HN ]
Re:The genomic era arrives, and this time is probably real
by haihaibye on Tuesday May 10, 2016 @07:25PM
(#11671490)
RNAseq, the measure of abundance of transcribed genes at a particular cell state is one of the most common assays done with next gen sequencing. That's the big one then of course there is also miRs, transcription factors, methylation, histone marks, chromatin conformation capture.
As someone with a CS background who has worked almost 5 years in bioinformatics, one thing to realise is if you think something obvious is not done, either you're missing the right search term on pubmed or there's some horrible lab issue that makes it really hard (and we need a new assay/tech)