> Tens of thousands ... are extinct thanks to our meddling.
Probably much more:
https://en.wikipedia.org/wiki/Holocene_extinction
"the present rate of extinction may be up to 140,000 species per year,[2] making it the greatest loss of biodiversity since the Cretaceous–Paleogene extinction event."
Tens of thousands of living things that used to call this planet home are extinct thanks to our meddling. I'd say that's proof enough we're badly f'ing things up.