I've experimented with lots of digital note-taking styles: mindmaps from open source to paid, notebooks like evernote, bookmarking systems, PPT flashcards...but none can really replace writing notes with hand. Its a lot faster, no accidental clicks, and drawing and annotating specific things are a non-brainer. When I got a highly sensitve tablet to actually write things in it, it still felt clumsy. I have to take pictures then import them into my notebook app, I have to switch pen colours and nib width, and then there's the ironic trouble of not being able to find a specific information I want, unless i do sophisticated tagging but that's also too much effort. And oh boy the panic that came with the battery running out halfway through a lecture.

Back to pen and paper for me, and loads of post-its for bookmarks.

I've tried dozens of different software suites to try and replicate hand written notes, and nothing else comes even close to handwriting (for me, at least)