Most of those fresh fruit and veggies are man-made, too. Modern tomatoes, corn, squash, broccoli (check out what we did to wild mustard plants: https://nicolecooks.files.wordpress.com/2011/01/f2104.jpg), etc. are nothing like what's found in nature. Your wine's probably closer to naturally occurring than they are - we get drunk squirrels from fermented fruits every year.