The mind behind Noise (Trevor Perrin) is one of the minds behind Axolotl (actually Noise can be seen as a generalization of the Axolotl's cross-signing of DH keys, see this post: https://whispersystems.org/blog/simplifying-otr-deniability/) so I would likely be comfortable with it. Although it is completely true that it's been far less used and studied than TLS.