The common thread though is that a single dose of the drug offers long-lasting protection, weeks or months or years. It's not about chemically changing the brain day after day, it's about using neurochemicals to jolt the brain out of a rut. It's about occasionally kickstarting the brain back into normal self-regulation, not using externally supplied chemicals to permanently supplement dysregulation.
Completely depends on the drug, person and context.
The painkillers when I dislocated my shoulder and they had to reset it? Wonderful.
The antidepressants that after several weeks (so once they'd started "working properly"), made me feel "not unhappy" but like a robot and then also gave me vivid, real nightmares in which I died horribly over and over again? Not so great...
I'd never touch antidepressants ever again. For some people they do work, but for others they don't. Yet we still push them on everyone.
Seriously though, compared to being depressed when you can't fix it because you don't have any idea that something is wrong, drugs are fucking amazing. The shitty part is people end up trapped now as the drugs can fuel the negativity which lead to the depression in the first place.