What I'd love to be able to do with tools like Unity3D that compile C# and other CLR languages into asm.js, would be to pass JavaScript objects directly in and out of the C# code so you can manipulate the underlying JavaScript objects directly from C# with little or no overhead.
Right now of course you can implement JSON libraries in C#, but it's indirectly and inefficiently layered on top of the flat memory model of asm.js. I want to be able to use the native JavaScript objects and libraries directly from other languages like C# that compile into JavaScript. That would be ideal!
To do that, asm.js would need a way to store references to garbage collected JS objects somewhere, somehow, using proxies or handles represented in linear memory, opaque reference types [2], or some other magic like that, like Apple's JavaScript/Objective C bridging stuff [3].
[1] http://bytecrafter.blogspot.nl/2015/06/a-quick-overview-of-w...
[2] https://github.com/WebAssembly/design/blob/master/GC.md
[3] https://developer.apple.com/library/mac/documentation/Cocoa/...