There are Common Lisp bindings to most of the common GUI toolkits like QT and GTK and OpenGL, there have been Carbon bindings for the Mac and probably there are some native Windows bindings. As most Common Lisp implementations have an interface to call C functions, there are no fundamental limits to what you could do. For basic needs, there is also a binding to TK written entirely in Lisp (http://www.peter-herth.de/ltk/index.html) which is simple to install and use.