It's unlikely the drone ship would be lost. The rocket is coming in nearly empty. The explosions we've seen in the past are really just the remnants of fuel briefly burning, it's not all that powerful. The rocket itself is light compared to the ship. It's a little bit like someone throwing a soda can at your head. It'll hurt, but it won't break your skull. Some of the support equipment on the deck might take damage (there are fun pictures of the ship after previous attempts with various items dented and scorched) but the ship itself should be fine.