People do commute to NYC; but it sucks from Poughkeepsie. The train is not 1 hour, it is 1 hour 45 minutes. You need to drive to the station and park, figure at least 15 minutes. That also assumes you're going to be working very close to 42nd street. Otherwise add another 20 minutes for the subway/walking.

You're lucky if this is going to be less than 2.5 hours each way.

I live 38 miles north of the city; Poughkeepsie is 73.5. It takes me about an hour and 45 minutes door-to-door to get to work at 22nd street. 10-15 minutes to the train station, probably about 5 minutes of waiting [because if you miss one train, you have to wait 20-30 minutes or so for another depending on the time of morning], 60 minutes on the train, then about another 25 minutes of walking (or alternatively 5 minutes to get to the subway, 2-5 minutes to wait for it, then 5 minutes on the subway, and another 5 minutes of walking).