More evidence emerges for 'transmissible Alzheimer's' theory

Re:More evidence emerges for 'transmissible Alzheimer's' theory by alexholehouse on Tuesday January 26, 2016 @05:21PM (#10976660)

Both this result and the preceding paper are also entirely consistent with the hypotheses that:

1) People who are susceptible to vCJD are more susceptible to AD

2) The (cellular) stress caused by vCJD increases susceptibility for AD

3) People who have had brain surgery (a traumatic and stressful experience in terms of brain swelling) are more susceptible to AD

All three of which would be entirely inline with the fields' current way of thinking about AD, proteostasis, CBI etc. Which is not to say I actually don't think that there is a transmissible element, but I think we should avoid jumping to conclusions...

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Re:More evidence emerges for 'transmissible Alzheimer's' theory by pc2g4d on Tuesday January 26, 2016 @05:43PM (#10976832)

But what about the CJD controls that didn't receive transplants derived from cadaver tissue? Those didn't show the same rate of Alzheimers-like plaques, if I understood the report correctly.

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Re:More evidence emerges for 'transmissible Alzheimer's' theory by alexholehouse on Tuesday January 26, 2016 @06:31PM (#10977092)

The CJD controls had sporadic (sCJD), not variant CJD (vCJD) (whether or not these are distinct diseases is certainly an open question - I'm more trying to make the point that there are a lot of variables up in the air, and while it's a striking relationship there are other equally striking relationships one could draw).

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Re:More evidence emerges for 'transmissible Alzheimer's' theory by pc2g4d on Wednesday January 27, 2016 @02:20PM (#10982323)

A good note of caution for any study.

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