Looks great, but I can't comment more as I haven't used it.

It looks to be solving the same problems as DNAnexus, Seven Bridges, BaseSpace etc as a way to wrap open source tools in more user-friendly ways.

But it's orchestrating the production of smaller set of data that still needs the next step of human interpretation, report writing, family-aware algorithms and most complex annotations (the problem space Golden Helix is in).

In other words, the automatable bits that is not the hard part that I mentioned in my blog post.