While the quote is true, it doesn't mean that being unreasonable should be a goal in itself. Indeed, destruction also comes from unreasonable people. It all depends on what it is you're really trying to accomplish. Is it something good? By all means, push harder to get there. But if it's something bad, then you may end up destroying more value than you create. A witty saying doesn't let you bypass ethics.

Change depends on the unreasonable man, but not all change is progress. Maybe listen to reasonable people to steer the change towards something good.

And it also comes with the same submission https://news.ycombinator.com/item?id=10567630

should be perfectly fine to hold extreme opinions. Bayesian distributions suggests that extreme opinions will be unpopular, and will not find much evidence from the real world, and will be less likely to gain mass following.

If only humans were rational bayesian reasoners...