Not if you are writing a software based switch, especially one designed to be scriptable.
Which the author is.
Context is everything.
Can you elaborate? Is a a software based switch exempt from the memory subsystem?
I'm not OC but reading the author's project list, it seems to me that he is working heavily in networking optimization in cases where packages are small enough that won't be invalidated from cache until they are done.
If that were true, then the memory subsystem has little to play in this. However, users of this still have to take the memory in consideration when sending packages, hence the OC's comment about context is everything.
No, the thing to worry about is the memory subsystem. How does the data interact with the caches? What DRAM access patterns do I have? How do I flow data as efficiently as possible?