Lots of your anti-prohibition activists are wealthy progressives and libertarians who, like me, like David Simon, have no personal stake in the outcome.
Then why have a big, green statue on an island off the shore of New Jersey? What does that stand for?
"A disordered country is full of loyal patriots."
It's just like the naive idea that the "non-aggression principle" determines how people should interact with each other. Suddenly every use of force that the speaker feels is justified is 'retaliatory' and every use of force they feel is unjustified is 'initiatory'.
The only coherence principles like this have are what people already commonly agree on. You don't need to base your politics on principles for that. They do not tell you how to harmonize ideological conflicts or develop and spread ideas that lack consensus.
Maybe if one or one's family hasn't been directly harmed by the drug war? I don't think such an abstract idea could possibly be the primary opposition to any policy. These state policies have physically destroyed communities and lives. People want their families, and they want to stop being oppressed by the police. They want the baton and tear gas out of their face. That's the primary opposition.
Abstract principles are always secondary to material reality.