vapemaster
grow up anthropic.
Sonnet 5 (Full Text)
Verizon Is Down
Claude Opus refuses to answer biotech questions
Claude Opus has started refusing to answer any moderately detailed question regarding biotech / drug discovery related tasks. Sonnet will still answer but at it's usual level of inaccuracy and vagueness that makes it unhelpful. Why would this pose a safety concern? What am I missing.ie prompt: I have a small molecule I want to optimize oral bioavailability for in cynos and humans, what is the...
X is blocking links to Signal
happy to see some light shown on the grim state of comp chem file formats and their shockingly lossy interconversion but I'm not sure that was the OP's intent?
Hot Take: Prompt engineering isn't engineering. It's discovery
I'm in the drug discovery space, and for all the "engineering biology" talk that's around these days, I find a bunch of parallels to drug discovery in the AI, particularly LLM space.The fact that these models get created and the poked and prodded with prompts reminds me a ton of chemical biology, aka the field of using chemicals to investigate biology.It would appear that in the case of AI, the...
How deep is the brain? The shallow brain hypothesis
This, 1000x this.
It's utterly bizarre that the window management paradigm is "let 'em all stack up and make it easy to spread 'em all out"
At first I thought I didn't get the paradigm. Now I get that I don't get the idea behind the paradigm.
Rectangle (pro version) fixes some of this and adds some really cool features. And because of the Apple app hegemony, it does work nearly OS level good. But why, oh why does this have to be 3rd party?
It's like some any UX pattern baked in since Lisa?
Griptape – a modular Python framework for LLM workflows, tools, memory, and data
I've been to aggressively remapping that I don't then create a similar problem when using another machine I don't own but maybe I'll give in and go the more custom route
Mac's command key is worse than Window's ctrl
Long time windows + occasional linux user. Switched to Mac for the M2 Mac Book Air. It's a phenomenal piece of silicon + hardware.Fairly shallow learning curve on the switch since so much is cross platform electron apps these days.BUT ... Good god the command vs ctrl behavior is driving me nuts! (even with tweaking using Karabiner etc.)First, the ergonomics of ctrl (left pinky stretch) + any...
but i just wish there were some talented engineering teams at the leading browser creators (cough couch google, mozilla, MS, apple, etc) that would integrate this as a first class feature. a design goal, not a supported extension.
Ask HN: Why are bookmarks second class citizens in browsers?
so much of my time is spent in chrome tabs / windows / and searches. someone's average chrome tab count is a badge of honor / horror. Chrome now hides the bookmark bar by default. you can create tab groups for a session, or pin them so that they consume all your bandwidth and memory next time you open your session.But that's not what i want.i want rich bookmark behavior.i want to be able to...
[weirdly, someone discovered an birthday overlap today at work and i just re-google/wiki'd this today]
Not trying to be snarky, but that's not how publishing works.. you don't get a paper retracted for criticism, you get it retracted if there was scientific malfeasance. And retractions are actually exceedingly rare.
In fact having criticism / debate around your paper is a great way to get more citations, the real publication currency in academia...
Then I sit back and realize that it's usually because most of the examples I read are trying to solve non-technical problem (attribution, trust, etc.) with a buzzy tech solution all wrapped in a serious bit of speculation.
I think there's a lot of room for improvement in the tech of our law, banking, and logistics systems (COBOL--> anything else?), but the kneejerk to some "decentralized" system that needs total but in from it's participants to work actually seems more fragmented and fragile than our current institutions...