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Re:Claude discovers a novel enzyme system with CRISPR-like repeats on Wednesday September 23, 2026 @11:37PM (#49825943)
this is with out a doubt the saddest excuse for "scientific discovery" i've ever read. even if there is novelty and eventual value from this line of inquiry, the excruciating lack of rigor, methods, or disclosure has francis bacon rolling in his grave.

grow up anthropic.

Re:Microscale Thermite Reaction on Friday May 15, 2026 @08:33PM (#48155664)
wow I hadn't heard of this but it's quite cool. aka Nano-Thermite

https://en.wikipedia.org/wiki/Nano-thermite

Re:Verizon Is Down on Wednesday January 14, 2026 @08:21PM (#46626653)
Thought I was going insane today.
Re:Collaboration sucks on Tuesday November 11, 2025 @04:53PM (#45893397)
You guys need to work on harder problems.

Claude Opus refuses to answer biotech questions

Claude Opus has started refusing to answer any moderately detailed question regarding biotech / drug discovery related tasks. Sonnet will still answer but at it's usual level of inaccuracy and vagueness that makes it unhelpful. Why would this pose a safety concern? What am I missing.ie prompt: I have a small molecule I want to optimize oral bioavailability for in cynos and humans, what is the...

( Read More... | no comments | 2 points | on HN )
Re:Ask HN: Weirdest Computer Architecture? on Thursday August 01, 2024 @03:45PM (#41132811)
since this is a bit of a catch-all thread, i'll toss Anton into the ring: a whole bunch of custom ASICs to do Molecular Dynamics simulations from D.E. Shaw Research

https://en.wikipedia.org/wiki/Anton_(computer)

Re:Leap – Chemistry Through a Computational Lens on Monday July 15, 2024 @06:45PM (#40972119)
not hating on the great amber - but why LEaP on the front page of HN with no context...?

happy to see some light shown on the grim state of comp chem file formats and their shockingly lossy interconversion but I'm not sure that was the OP's intent?

Hot Take: Prompt engineering isn't engineering. It's discovery

I'm in the drug discovery space, and for all the "engineering biology" talk that's around these days, I find a bunch of parallels to drug discovery in the AI, particularly LLM space.The fact that these models get created and the poked and prodded with prompts reminds me a ton of chemical biology, aka the field of using chemicals to investigate biology.It would appear that in the case of AI, the...

( Read More... | 2 comments | 2 points | on HN )
long time windows user that switched to mac due to Apple Silicon dominance on the laptop experience.

This, 1000x this.

It's utterly bizarre that the window management paradigm is "let 'em all stack up and make it easy to spread 'em all out"

At first I thought I didn't get the paradigm. Now I get that I don't get the idea behind the paradigm.

Rectangle (pro version) fixes some of this and adds some really cool features. And because of the Apple app hegemony, it does work nearly OS level good. But why, oh why does this have to be 3rd party?

It's like some any UX pattern baked in since Lisa?

Re:Zrok: Open-Source Peer to Peer on Wednesday February 08, 2023 @05:43PM (#34716636)
this was an awesome, non-snarky, explanatory comment. thanks for this.
Re:Mac's command key is worse than Window's ctrl on Monday January 30, 2023 @08:53PM (#34589833)
touché
Re:Mac's command key is worse than Window's ctrl on Monday January 30, 2023 @10:28AM (#34580908)
except that you still use command to copy and paste in the terminal
Re:Mac's command key is worse than Window's ctrl on Monday January 30, 2023 @10:28AM (#34580892)
agreed, the fold under makes me use the side of my thumb on command which is much less natural or tactile than stretching my pinky to use the pad.
Re:Mac's command key is worse than Window's ctrl on Monday January 30, 2023 @10:23AM (#34580830)
I immediately had to get Karibiner to at least give me my home and end keys back on a external keyboard.

I've been to aggressively remapping that I don't then create a similar problem when using another machine I don't own but maybe I'll give in and go the more custom route

Re:Mac's command key is worse than Window's ctrl on Monday January 30, 2023 @10:21AM (#34580777)
well [ctrl] + <down arrow, F4, F5> are used for window management by default
Re:Mac's command key is worse than Window's ctrl on Sunday January 29, 2023 @04:48PM (#34573111)
agreed, I'm almost to muscle memory with it so it's not the "i have to think about it" annoyance, it's that my whole hand has to move to make it work... noticeably slower than my windows workflows..

Mac's command key is worse than Window's ctrl

Long time windows + occasional linux user. Switched to Mac for the M2 Mac Book Air. It's a phenomenal piece of silicon + hardware.Fairly shallow learning curve on the switch since so much is cross platform electron apps these days.BUT ... Good god the command vs ctrl behavior is driving me nuts! (even with tweaking using Karabiner etc.)First, the ergonomics of ctrl (left pinky stretch) + any...

( Read More... | 29 comments | 3 points | on HN )
just me typing too quickly for my own brain, thanks for the correction!
cool i'll check out raindrop, thanks for the tip!

but i just wish there were some talented engineering teams at the leading browser creators (cough couch google, mozilla, MS, apple, etc) that would integrate this as a first class feature. a design goal, not a supported extension.

savage. but case and point!

Ask HN: Why are bookmarks second class citizens in browsers?

so much of my time is spent in chrome tabs / windows / and searches. someone's average chrome tab count is a badge of honor / horror. Chrome now hides the bookmark bar by default. you can create tab groups for a session, or pin them so that they consume all your bandwidth and memory next time you open your session.But that's not what i want.i want rich bookmark behavior.i want to be able to...

( Read More... | 263 comments | 271 points | on HN )
Re:Preparedness Paradox on Monday August 15, 2022 @07:01PM (#32476660)
i always heard it called the birthday problem: https://en.wikipedia.org/wiki/Birthday_problem

[weirdly, someone discovered an birthday overlap today at work and i just re-google/wiki'd this today]

Re:Why does science news suck so much? on Sunday June 19, 2022 @12:21PM (#31800739)
> If someone criticizes your paper, and it gets pulled from publication, then thats the same as having never published anything in the first place. Therefore, the technique to survival is to write your paper in such a way that repels criticism as much as possible.

Not trying to be snarky, but that's not how publishing works.. you don't get a paper retracted for criticism, you get it retracted if there was scientific malfeasance. And retractions are actually exceedingly rare.

In fact having criticism / debate around your paper is a great way to get more citations, the real publication currency in academia...

Re:Tea – the toolkit that builds the Internet on Wednesday March 23, 2022 @11:59AM (#30779847)
When I read web3 co.'s product/ tech description it almost always feels like some form of tech. literacy gaslighting. I always feel initially like there's something elusive that I'm not grokking b/c I'm not a blockchain zealot.

Then I sit back and realize that it's usually because most of the examples I read are trying to solve non-technical problem (attribution, trust, etc.) with a buzzy tech solution all wrapped in a serious bit of speculation.

I think there's a lot of room for improvement in the tech of our law, banking, and logistics systems (COBOL--> anything else?), but the kneejerk to some "decentralized" system that needs total but in from it's participants to work actually seems more fragmented and fragile than our current institutions...

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