t_serpico

I think the focus on building things is the wrong framing - that seems to be still there. But this AI wave is centered around automation, which has a different flavor to the previous cycles (1970-2010), which very much felt much more positive sum and less hyper capitalistic.

how so? (i'm not too familiar)

nice stuff! how do you handle security concerns big pharma may have? wouldn't they just run their stuff on-prem?

I actually thought the opposite - that he seems to be seriously thinking about AGI from a broader intellectual standpoint than most ML researchers. With that said, I was a little confused when he said evolution was more optimized for locomotion/vision than language. Like yes, language is super recent, but communication in general is not.

Yup, Dwarkesh needs to broaden his intellectual scope, and the Sutton interview completely exposed the echo chamber he's been inhabiting. There is no certainty in science, and I don't think building 'AGI' will be any exception.

this is a joke... to even call this a scientist is an insult.

But there is no way to know who is truly the 'best'. The people who position and market themselves to be viewed as the best are the only ones who even have a chance to be viewed as such. So if you're a great researcher but don't project yourself that way, no one will ever know you're a great researcher (except for the other great researchers who aren't really invested in communicating how great you are). The system seems to incentivize people to not only optimize for their output but also their image. This isn't a bad thing per se, but is sort of antithetical to the whole shoulder of giants ethos of science.

My practical interpretation of the EMH is more that easily accessible, public information is already priced in. But non-obvious insights may not be simply because the volume of people trading on that information will be smaller.

brilliant

The answer stems from McCarthy’s deeply disparaging view of modern society, which he considered lost, divorced from nature, history and tradition and heading toward social collapse and apocalypse. “Cormac considered contemporary fiction a waste of time,” said Dennis, “because contemporary writers no longer have a legitimate culture to feed their souls.”

'Seeing' inside cells/tissues/organs/organisms is pretty much most modern biological research.

Was going to comment exactly this - funny that it's a literal car salesman.

One fundamental challenge to me is that if each training run because more and more expensive, the time it takes it to learn what works/doesn't work widens. Half a billion dollars for training a model is already nuts, but if it takes 100 iterations to perfect it, you've cumulatively spent 50 billion dollars... Smaller models may actually be where rapid innovation continues simply because of tighter feedback loops. O3 may be an example of this.

I don't think he got taken for a ride. Rather, he also wanted to believe that AlphaChip would be as revolutionary as it claimed to be and chose to ignore Chaterjee's reservations. Understandable, given all the AlphaX models coming out around that timeframe.

"Topology is all that matters" --> bold statement, especially when you read the paper. The original authors were much more reserved in terms of their conclusions.

Exactly my thoughts, the AI shields all responsibility from the humans.

To call this memory seems like a stretch. By the logic of the article, every daughter cell has 'memory' of the parent cell because some proteins from the parent cell are present in the daughter cell. I would be curious to see p53 complex concentration as a function of cell generation/mitosis time to show how durable this 'memory' actually is.

https://onlinelibrary.wiley.com/doi/10.1002/bies.201300153 tl;dr: metabolism is all you need.

while potentially interesting work, very shortsighted and premature to say this is a "GPT" moment in biology. ML people in bio need to think hard not only about what they are doing, but why are they are doing it (other than this is cool and will lead to a nice Nature publication). Their basic premise (learning from DNA is the next grand challenge in biology) is shaky. Imo, the grand challenge in biology is determining what the grand challenge is, and that is a deep scientific/philosophical question.

i'd wager that adding noise to the weights in a principled fashion would accomplish something similar to this.

if you just want count/location, super resolution techniques (https://www.science.org/doi/10.1126/science.ade2676) and proximity labeling (https://www.biorxiv.org/content/10.1101/2023.10.28.564055v1) may be a good starting point. cryo may be able to help with that if the direct electron detectors get better (as my understanding (and in my experience), cryo-et data is quite noisy). my guess is that multiple techniques will have to be combined and processed with sophisticated computational pipelines to make this a reality. each technique provides some information on the state of the cell, so the computational question becomes if can you figure out how to integrate information between these techniques to get the specific information you want. it may be too early to tackle this, but who knows...

Sure, nothing fundamentally prevents us from repairing it from a physical standpoint. The practicality of it is the key question. While the machine analogy is partially useful, genes/proteins/cells are dynamic, adaptive, and can exhibit stochastic traits. This fundamentally contrasts them from traditional machines, and is the reason (imo) we suck at making effective therapies to even treat diseases where we think we know what is going on.

Most of his guests are quite intelligent. His style generally works well with people who have expertise in something or are just generally deep thinkers. He also picks interesting guests that people are generally aware of (sometimes). The mainstream guests are the by far the worst interviews, the PG one being a great example.

To add on to this, unbridled capitalism also leads to more goods and services affordable for the average consumer. This makes the idea of taking a lower paying job appealing because you can still live a fairly comfortable life.

How have I missed the point? The answer that nature cannot engineer and can't start de novo are trivially true statements that provide no actual insight into the question. I fully agree the original question itself is a deep one. A quick literature search is more productive than pontificating with weak analogies. See https://www.math.unl.edu/~bdeng1/Papers/DengDNAreplication.p... for what seems to be an interesting analysis regarding base number and DNA replication rate.

A classic armchair response. DNA has complementary nucleotides (AT,GC) that facilitates its pairing. Base 3 wouldn’t work in that sense. Also, you can’t forget about the genetic code. See https://arxiv.org/pdf/q-bio/0605036.pdf for interesting thoughts. Remember, evolutionary biology is a field and people think about these questions!

agreed, if you have a theory, you should do your best to disprove it. OP was more interested in the aesthetic of their theory as opposed to whether it was true or not.

solving problems to solve problems we have created - openai

anyone else worried about how tools like this will make us dumber?