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> Osteoarthritis occurs when a joint is stressed by aging, injury or obesity. The chondrocytes begin to release pro-inflammatory molecules and to break down collagen, which is the primary structural protein of cartilage. When collagen is lost, the cartilage thins and softens; the accompanying inflammation causes the joint swelling and pain that are hallmarks of the disease.

Collagen synthesis in the human body can be aided by hydrolyzed collagen, Vitamin C, zinc and copper.

Re:Bleg: Where Is the DevOps for Yocto? on Saturday September 27, 2025 @11:14AM (#45396409)
> I wonder why nobody has set up, e.g., a good Yocto CI/CD base image pipeline for custom hardware devices

The near-infinite flexibility of OpenEmbedded/Yocto is a blessing and curse.

The Yocto autobuilder [1] covers board families, but hardware-specific layers [2] and BSPs are maintained by vendors and consultants [3].

Wind River Linux [4] offers long-term commercial support for regulated industries, derived from Yocto LTS, https://www.windriver.com/products/linux

Some work was done on a "Reference Binary Distro" to make Yocto more accessible to new developers, https://www.youtube.com/watch?v=7plHWCHGv1c

Funding has slowly diversified beyond hardware vendors, e.g. https://www.sovereign.tech/tech/yocto

[1] https://dashboard.yoctoproject.org [2] https://layers.openembedded.org [3] https://www.yoctoproject.org/community/consultants/

Ask HN: Dexcom Follow invitation expired or used b/c app store location

Attempting to share glucose sensor data across country borders, via the Dexcom Follow app, yields an opaque error message to the recipient: "This invitation expired or was already used. Ask your Sharer to invite you again."From https://www.reddit.com/r/dexcom/comments/1dhxnv9/comment/l90jytv/ "The CGM and Follow app have to both point to the same server region. The CGM data is stored in one of...

( Read More... | no comments | on HN )
Re:L. E. Modesitt, jr. interview (2024) on Friday August 08, 2025 @06:27PM (#44842331)

  What advice would you give to a younger L. E. Modesitt, Jr. at the beginning of his writing career?
> I wouldn’t even try. I like where I am, but getting here was so unplanned that any advice given to me at that age likely would have ruined me or made the journey seem so impossible that I might not have even tried.
In theory, LLMs could review more sources for a personalized risk assessment. But a brief query on this subject yielded generic responses from multiple LLMs :(
Re:Risk of dementia following gabapentin prescription on Friday July 11, 2025 @11:12AM (#44533061)
Earlier thread (50 comments), https://news.ycombinator.com/item?id=44527484
The smallest dose of pregabalin/lyrica is 25mg. After reducing to that minimum, it still took months of further tapering by dividing capsules, before withdrawal symptoms ended in one elderly patient. Pregabalin suppresses nausea, which means nausea is a symptom of withdrawal, requiring ginger tablets or other anti-nausea assistance during tapering.

https://www.thetimes.com/uk/article/an-anxiety-drug-killed-m...

> An investigation by The Sunday Times has revealed that pregabalin has the fastest-rising death toll of any drug in the UK, based on figures compiled from official data across all regions. It is detected in a third of all drug-related deaths. In 2012, pregabalin was indicated in nine fatalities. A decade later, in 2022, the number had risen to 779, with almost 3,400 deaths in the past five years.

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