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rfinney

rfinney on Hacker News

Re:US Bars Entry to International Criminal Court Investigators on Friday March 15, 2019 @03:44PM (#19403467)
ICC has no jurisdiction in the United States. U.S. did not ratify the treaty. No point in letting them pretend they do.

Imagine European idealists prosecuting Clinton, Bush and Obama for "war crimes"? No way.

Re:US to build six nuclear power plants in India on Thursday March 14, 2019 @07:24PM (#19394931)
India started developing nuclear weapons in the 1950s and first tested a nuclear bomb in 1974.
Re:Google Moves to Address Wage Equity, and Finds It’s Underpaying Man... on Monday March 04, 2019 @03:45PM (#19305236)
"non major liberal cities"

I think the "me too" thing proved the coastal elite were part of the problem.

Re:Show HN: I wrote a book about WebAssembly on Thursday February 28, 2019 @09:23PM (#19277458)
This provides access to hundreds of public and tens of thousands of restricted access cancer genomes (and often the matching "normal" samples): so you can see and visually verify mutations. Interestingly, too, you can check out germline polymorphisms which might predispose someone to get cancer.

Basically all the work is done in the browser : gzip decompression, custom parsing of sequencing alignment, png generation, etc. Lots of data are pushed to the client at load time like gene location information for genome build "hg38" (the latest). Server only provides reference sequence and sample genomic alignment "slices" for the region of interest. So, all the state is handled in the browser, server only provides trivial "wget" requests.

It is mostly wasm (source is C compiled with emcc). The front page is the requisite html/javascript start page. Pages are created in wasm code and pushed to JS for updating the DOM. Lots of calls to emscripten_run_script("your javascript here"). DOM manipulation straight from Rust/Go/C would be cool but it is not here yet.

Upside is server simplicity and security ... and no downloading and setting up complicated software.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987889/

Code is done by the government so it's public domain. (Your tax dollars at work !)

Re:Show HN: I wrote a book about WebAssembly on Thursday February 28, 2019 @09:00PM (#19277353)
NCI Chromatic - Cancer Genomes with WebAssembly:

https://chromatic.nci.nih.gov/

Re:Visa, Mastercard mull increasing fees for processing transactions: WSJ on Friday February 15, 2019 @03:55PM (#19174625)
We did. We had American Express, Diner's Club, Discover (the old Sears) ,department store cards, gas station cards, Bankamericard (Visa) and Interbank (Mastercard). In the 1960s there were hundreds of credit cards. Visa and Mastercard won the free market battle.
Re:Americans Cross Border into Mexico to Buy Insulin on Thursday February 14, 2019 @05:15PM (#19166595)
Key phrase from the article is "modern generation of insulin". A good overview of the design and effects of the new insulins are here : https://onlinelibrary.wiley.com/doi/full/10.1111/dme.13692 ( "Lessons for modern insulin development" ).
Re:Two Large Chinese Borrowers Miss Bond Payments, Sources Say on Tuesday February 12, 2019 @10:31PM (#19150127)
http://statisticstimes.com/economy/countries-by-projected-gd...

US: $62,152 Japan : $40,849

Re:The U.S. Is Getting Closer to a Recession, Data Show on Tuesday February 12, 2019 @11:34AM (#19144945)
Fair enough, we should adjust for inflation.

From Brookings : "Real median household income grew roughly 1.6 percent in 2018" https://www.brookings.edu/blog/up-front/2019/01/31/household...

Median household income : $60K . $60K * 0.016 =$960.

Re:The U.S. Is Getting Closer to a Recession, Data Show on Tuesday February 12, 2019 @11:03AM (#19144602)
https://www.cnbc.com/2019/02/01/nonfarm-payrolls-january-201... : On a year-over-year basis, though, [wages] still amounted to a 3.2 percent increase, consistent with the past few months and around the highest levels of the recovery.

Higher wages are a good thing.

Re:The U.S. Is Getting Closer to a Recession, Data Show on Tuesday February 12, 2019 @10:58AM (#19144545)
U.S definitely is not in a recession. https://www.calculatedriskblog.com/2019/02/bls-job-openings-... : BLS: Job Openings Increased to Series High 7.3 Million in December .

"Professional forecasters see economic growth easing to 2.4 percent in 2019." "The unemployment rate is forecast to average 3.6 percent in the fourth quarter of 2019, down slightly from four quarters earlier." : https://www.stlouisfed.org/publications/regional-economist/f...

Not a recession.

Re:NBC took Bob Costas off the Super Bowl for speaking out about concu... on Monday February 11, 2019 @04:42PM (#19138628)
Look again at the the PFF (Pro Football Focus) link in my post which the moderators flag banned : https://www.profootballfocus.com/news/fantasy-football-metri... .

Check out the PFF grades in the graphic for the last 2 years of his career: way, way down : https://media.profootballfocus.com/2017/05/Kaep.jpg. Way below average. NFL careers tend to decline after age 25. Kap was looking at 30. He was past his prime and riding the bench. He was not banned from the NFL, he lost a step. It happens.

BTW, your link has the narrator questioning why Goff and Cam Newton have jobs but Kap doesn't. What the what? Seriously. wth?

Re:Krugman Sees Possible U.S. Recession with Little Fed Wiggle Room on Monday February 11, 2019 @01:27PM (#19136840)
A very old joke: economists have predicted 9 out of the last 5 recessions.
Re:Millennials still recognise songs from music’s 1960s-90s golden age... on Sunday February 10, 2019 @09:40PM (#19131660)
A thought here: Multitrack recording appeared in 1955 : https://en.wikipedia.org/wiki/Multitrack_recording. Multitracking opened a new, fertile valley for exploration and did usher in a golden age of pop music that was truly "poplar music". It also made a lot of money. The industry peaked about the year 2000 when napster ( https://en.wikipedia.org/wiki/Napster) blew the bottom out of sales . The industry makes about 1/3 of what it used to ( see https://www.visualcapitalist.com/music-industry-sales/ for a graphic on how much revenue has declined ). MP3 killed the video star.

There's still innovation and new stuff. People can make any sound they want on their laptops these days.

There's a lot less incentive to go into the business for talented people.

Re:‘Trojan horse’ drug treated British patients with six different for... on Sunday February 10, 2019 @09:15AM (#19127832)
7 February 2019 Lancet paper on Tisotumab vedotin trial here : https://www.thelancet.com/journals/lanonc/article/PIIS1470-2... (entitled: "Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1–2 trial")

Tisotumab vedotin is a first-in-human antibody–drug conjugate that is directed against tissue factor expressed on the cell surface of tumour cells to deliver a clinically validated toxic payload to tumours. [...] Tisotumab vedotin is comprised of a fully human monoclonal antibody specific for tissue factor conjugated to the microtubule-disrupting agent monomethyl auristatin E (MMAE) via a protease-cleavable valine-citrulline linker. .... The study was funded by Danish and US biotech companies Genmab and Seattle Genetics

This Lancet paper references this 2014 Cancer Research paper: https://www.ncbi.nlm.nih.gov/pubmed/24371232?dopt=Abstract (http://cancerres.aacrjournals.org/content/74/4/1214.long) : "An Antibody–Drug Conjugate That Targets Tissue Factor Exhibits Potent Therapeutic Activity against a Broad Range of Solid Tumors"

Seattle Genetics page on Tisotumab Vedotin : http://www.seattlegenetics.com/pipeline/tisotumab-vedotin

Our [antibody-drug conjugate] technology combines the specificity of monoclonal antibodies, innovative linker systems, and the cell killing power of potent cytotoxic agents to treat cancer.

Interestingly, Seattle Genetics stock is down 12% on Friday: https://finance.yahoo.com/quote/SGEN ("cuz earnings"). Genmab was up 0.69% : https://finance.yahoo.com/quote/GEN.CO

Re:Conversations among German Nuclear Physicists at Farm Hall (1945) [... on Friday February 08, 2019 @12:47PM (#19116749)
[edited to remove mis-information ] apologies!
Re:Crunching 200 years of stock, bond, currency and commodity data on Thursday February 07, 2019 @02:37PM (#19107817)
From https://investresolve.com/blog/over-two-centuries-of-global-... (linked to in the bloomberg article) :

Trend and momentum are defined as the 12-month-minus-1-month excess return. While this is consistent with traditional measures of cross-sectional momentum, “trend” as proposed by Moskowitz, Ooi and Pedersen; and Hurst, Ooi and Pedersen does not impose a skip month. The current authors make the case that a skip month is more conservative because it allows for a delay in data diffusion in very early periods.

Re:Why are millennials burned out? Capitalism on Monday February 04, 2019 @11:12PM (#19082969)
Young people have exalted notions, because they have not been humbled by life or learned its necessary limitations; moreover, their hopeful disposition makes them think themselves equal to great things - and that means having exalted notions. They would always rather do noble deeds than useful ones: Their lives are regulated more by moral feeling than by reasoning - all their mistakes are in the direction of doing things excessively and vehemently. They overdo everything - they love too much, hate too much, and the same with everything else.

– Aristotle

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