rdgthree
Solubility in olive oil predicts anasthetic potency of a compound
A dead fish moves upstream when its body resonates with vortices in water [pdf]
Alzheimer's disease starts in childhood in polluted Mexico City (2020)
Incidence of Dementia Before Age 65 Among 9/11 Attack Responders (2024)
From 2024:
> Transcranial magnetic stimulation (TMS) is a non-invasive, FDA-cleared treatment for neuropsychiatric disorders with broad potential for new applications, but the neural circuits that are engaged during TMS are still poorly understood.
[0]https://journals.plos.org/ploscompbiol/article?id=10.1371%2F...
But also:
> Although the biology of why TMS works isn't completely understood, the stimulation appears to affect how the brain is working.
https://www.mayoclinic.org/tests-procedures/transcranial-mag...
I think it's reasonable to assume there's room to sharpen our understanding of it quite a bit.
This was where I started pulling this thread (October 2025): https://1393.xyz/writing/could-the-root-cause-of-alzheimers-...
And this is an even further ancestor of the ideas (December 2023): https://1393.xyz/writing/are-we-only-conscious-while-were-le...
I'm operating off of my own subjective experience, and this idea lines up tightly with System 1 and System 2 in cognitive psychology.
It seems that many jump to "AI psychosis" when one mentions magnetic fields, but the evolutionary tree is very straightforward:
1. Nature evolves magnetoreception for navigation
2. Eventually, a brain in nature with magnetoreception accidentally "hears" its own magnetic field with with resonance
3. That lossy global summary of the brains ends up being an evolutionarily advantageous "higher-order sense"
4. Evolution sharpens the blade for many years
On first principles, that seems perfectly viable and even likely given that magnetoreception was such a boon for survival for all life.
Just glad others are finding it interesting!
Independently, since the whole idea relies on resonance, it may be the case that an fMRI doesn't actually interfere with the "stochastic resonance" mechanic quite like TMS (transcranial magnetic simulation) seems to.
If you model the brain this way, dementia looks like a clear breakdown of System 2, which is an interesting thought experiment even if the mechanics aren't perfect: https://1393.xyz/writing/alzheimers-is-the-symptom-not-the-p...
Modeling two physical systems is pretty interesting though because dementia ends up looking like a clear failure of System 2. Really neat idea generator even if imperfect.
So, when you get tired, System 2 leans more and more on the much more energy efficient System 1. So you get behaviors that look like unrestrained habits: poor impulse control, lowered emotional regulation, etc
Edit: I wrote more about this idea if anyone is curious: https://1393.xyz/writing/alzheimers-is-the-symptom-not-the-p...
If a Meta AI model can read a brain-wide signal, why wouldn't the brain?
Alzheimer's is the symptom, not the problem
Could the root of Alzheimer's be magnetic?
The brain and body are effectively locked in a paranoid "fight" state - "I know this behavior is unhealthy, but if I don't behave this way, then [insert irrational fear] will happen."
If you can figure out what she is afraid of, you might be able to help her walk back the behaviors from there. But trying to correct the behaviors on their own is very hard. Since the fear is usually irrational, the behaviors may be a relatively rational response to said fear. They may hold the fear itself as table stakes - not understanding that they are afraid of something that isn't real (i.e. I will never find love if I'm not as skinny as the other girls on Instagram).
Again IME - the feeling from inside the self-destructive brain is "I shouldn't be doing this self-destructive behavior, but I don't know another way to achieve X goal, and I absolutely need to achieve X goal." Asking the question "Why do you need so badly to achieve X goal?" is usually a good start to defanging the fear.
Are we only conscious while we're learning?
I don't want to say this makes me feel hopeless, because it genuinely doesn't. I'm working on a new startup, I'm starting a family, and I'm doing well.
I just want to build things that matter, that people find useful, and I've been having a hard time figuring out how I'll do that in a world with sufficiently advanced AI. Hobbies have never been enough for me, and never will be. It needs to be more than fun to energize me - I need to feel like I'm moving a needle.
For now, all I know is that I don't know. It feels nearly impossible to guess what the future holds.
Anecdotally, my company had an office team and a remote team split about 50/50 before and unrelated to COVID, and it was tricky. We don't have a lot of meetings, but when we did, it was hard to have a physical group in a conference room with a remote group on a screen. We solved that by effectively going fully remote for meetings that involved remote employees - everyone who was physically in the office would connect to a video call at their individual desks. I was personally fine with it, but some people definitely prefer (and work better in) that physical conference room setting.
All of that to say, the way one person works might be a forcing factor for others, even if they don't intend for it to be. Tricky problem.
I've been rejected/failed/banned by an emotionless machine a handful of times, and I don't know that anything else has made me feel quite so hopeless. I like to think a similar knot in my stomach keeps me honest.
Thankfully, one of our fundamental incentives as a property management business is to get more quality tenants approved for more apartments. If there are high quality renters qualified to sign a lease and fill a vacancy, mistakenly rejecting them directly impacts a landlord's bottom line. So we're motivated beyond altruism to get this right, which is important.
Along these lines (and perhaps surprisingly, relative to the automation in the post), our income verification product is decidely not fully automated. Non-salaried income reporting can be extremely tricky, and we've run into a number of renters with reliable income on a monthly basis that doesn't fit neatly onto a bi-weekly paystub. In those circumstances, we work with them manually to sort out how we can best present it to landlords on an application.
We replaced rental brokers with software and filled 200 vacant apartments
> React’s team enjoy experimenting with new ideas, but this is killing the ecosystem! They should be brave and take the blame for it!
Have to make a lot of assumptions with this sort of thing, but I can't imagine that attitude results in high quality engineering work.