notamy

> Mitochondria have been demonstrated to utilize quantum tunneling in their function as the powerhouse of eukaryotic cells.

> Parsing millions of URLs per second

To me that reads like it was trying to accomplish something like

    int[] current;
    while((current = queue.pop()) != null) {

I now wonder if they use the sound to communicate with other plants to try to get clouds to form faster

It does not. The cobalamin molecules are quite large and don’t penetrate the sublingual mucosa very well. On top of that, the proteins in saliva that bind to B12s will cause any bound B12 to not absorb sublingually, instead having to wait to make it through the digestive system for intestinal uptake.

Sublingual is still certainly a better option than oral pills, but the injections are preferable in severe cases for a reason.

https://www.researchgate.net/profile/Osama-Arafat/publicatio...

> METHYLCOBALAMIN HAS AN EFFECT ON HYPOTHALAMIC–HYPOPHYSEAL– ADRENAL AXIS

In rats, but may apply to humans too.

Prolonged copper deficiency can cause irreversible neuropathies and CNS damage. You should try to get tested for it if you can.

B9 and B12 are interdependent. When the body uptakes cobalamins, the ligands are pulled off and replaced with ligands sourced from other processes. IIRC in the case of methylcobalamin, the methyl group is pulled off and replaced with a methyl group that’s moved over from methylfolate via a riboflavin-dependent reaction. Been a hot minute since I looked into this so I may have some details incorrect.

Yup, not everyone can convert cyanocobalamin or hydroxocobalamin to adenosyl-/methylcobalamin. Especially in severe cases, anecdotally I’ve seen people not make progress with the standard cyanocobalamin injections, but then make huge progress with methylcobalamin injections. Unfortunately, methylcobalamin is often not preferred in injectable form due to very quick degradation into hydroxocobalamin upon exposure to light.

[1] https://en.wikipedia.org/wiki/Small_intestinal_bacterial_ove...

[2] https://en.wikipedia.org/wiki/Metformin CTRL-F "B12"

/soapbox

Get your B12 tested (before taking supplements!).

B12 deficiency is known to present in many ways, and also to be often overlooked in clinical settings[1]. It’s known that not everyone presents with the anaemia from it[2], which is often why it’s skipped as a diagnostic option. Additionally, long-term/severe deficiency can present with symptoms almost identical to multiple sclerosis[3]. Deficiency of other B vitamins, such as B2, can cause a functional B12 deficiency as well[4]. It’s also known that supplementation will falsely elevate levels even in the presence of a deficiency.

/unsoapbox

[1] https://www.mcpiqojournal.org/article/S2542-4548(19)30033-5/...

[2] https://www.bmj.com/content/383/bmj-2022-071725

[3] https://researchonline.nd.edu.au/cgi/viewcontent.cgi?article...

[4] https://www.iomcworld.org/articles/paradoxical-vitamin-b12-d...