negura

The issue is mainly with HN users not bothering to read the submissions and just writing armchair commentary on either side of the debate.

The authors of this study have identified the upstream protein responsibile for the anti-ageing effects in mice, that this protein has anti-senescent effects on human cells, that this protein drops with age in humans, that it drops more in humans with age-related disease and that this protein could have a protective effect in multiple chronic diseases in humans based on mendelian randomization.

This implies a stronger therapeutic potential than just a "nothingburger study".

The paper mentions briefly how it would translate as human therapy:

> Importantly, DTAL was safe as the internal loads on the human tibia were predicted to be as high as 4.7× body weight, which is within physiological limits67 (∼3,000 N for a 65 kg individual), as instantaneous contact forces to the tibia can reach 6× body weight during running.68

I wonder if skipping rope/hopping might be the best way.

> This is essentially what the article is saying. This all only hasn’t collapsed because money lenders haven’t pulled the plug yet.

That is not what the article is saying. At all.

> Warning signs would include a downshift in businesses’ AI usage, cheaper pricing or fewer customer commitments.

> We’re not seeing any of those yet.

> we’re cognitively capable of conceiving of less than 1% of

If you can't conceive it, then you can't take a percentage of "it", since you've not conceived that "it".

I've filtered the generative proposals for biology [0] because that's a field I'm a bit familiar with. I think it's a bunch of nonsense, tho the confident language really gaslights me.

[0] https://lacuna.tiptreesystems.com/explore?view=hypotheses&q=...

You mean something like.. a purge.. of the deep state? I think I heard that idea before

I kept reading and reading for that point to be made in the article, and it was burried right at the end. That's the most important part. It seems all the miracle benefits of GLP-1 so far can be explained by basically going on a diet.

Addiction engineering! One of the most influential developments in tech to emerge out of San Francisco. You're right, there's nothing really new about this.

> outside of a world war.

There you go. After ww2 USA just inflated away its debt. It's actually chartered territory.

Their models are already highly capable. They have enough leverage to act like scumbags, yet unlike Americans, they lack the compulsion for it. That authoritarian regime you fearmonger about has in fact done an excepetional job for its people over the last half century.

> Not likely the case in 2015 Apple nor probably even now

I disagree, I think it's 100% Apple to do that.

There are multiple vendors which ship devices with IME disabled and instructions for flashing coreboot (or they ship with it pre-installed). And Apple is much closer to Windows than it is to a GOS phone and self-hosted infra. The options are there for the people who actually care.

The only new thing (to me) was the observation that some of our societal timeframes (e.g picking a 4yr university degree) hinge on assuming a specific rate of societal change. If the rate of disruption exceedes that assumption, the timeframes become inadequate.

> AI is developing faster than humans can individually and collectively understand it and adapt to it. People trying to plan their futures, e.g. trying to plan for a world several years in the future as they enter university, can no longer do so the way previous generations could.

> I’m also very concerned about other AI-related issues: cognitive surrender, AI-induced psychosis and loneliness, power concentration, economic disruption, cybersecurity, lack of accountability, and so on.

I'm so bothered that we seem to have moved on from the ATTRIBUTION problem with LLMs. It just isn't on people's minds anymore, even tho it STILL is a big deal.

I really don't understand this. That's how you make your security decisions? Based on something you've read about Tim Cook in the news? But no third party audit, no open source code, no decentralization, zero self-hosted infrastructure? You put all your data in a black box that someone else controls fully, but hey, at least they took the FBI to court once? And on top of that considering this is Apple, well known for dazzling people with superficial first-impressions, into making bad long-term choices?

I never heard of that. Is this documented anywhere? Also doesn't Apple Store usually replace the whole device for a repair, rather than individual hardware components?

First world problem if there ever was one.

And enjoy the anonimity of downvoting this, for now. But don't fool yourself that your complicity isn't noted.

The takeaway from this is very important, and always missed: the people at the top were, are and always be intentionally political, ideological and conspirational in their activities (Drew does a good job proving that). And what benefits them the most is exactly the kind of asymmetry which is created when everyone else keeps politics out of their conversations.

> Please don’t use Hacker News for political or ideological battle. It tramples curiosity.

The nagging notifications are only a small part. Apple has far more effective ways of forcing updates on you. On iPhones, for instance, the Unicode tables ship with the OS version, so unless you update, you cannot render newly added emoji codepoints. Given how central emojis have become to pop culture - and how determined the Unicode Consortium seems to keep adding more of them - the whole situation almost looks like a conspiracy, if you squint. But that's just the tip of the iceberg.

In the App Store, Apple won't let you filter for apps compatible with your iOS version. So sooner or later, you have to manually try installing every search result just to see whether it errors out. There's no explanation for not adding such a trivial filter other than to annoy users on purpose. Without jailbreaking, you also can't install earlier (compatible) versions of a given app. And by the way, updating iOS eventually just turns into buying a new iPhone, once the latest iOS no longer supports your device at all.

But the worst part is how critical software components are bundled with the OS too. On iPhone, that means WebKit. So very soon your Internet browsing experience starts to rot, because the only way to get a version supporting the latest Web standards is to update the whole of iOS. Likewise, on Macs, your runtimes/frameworks are bundled as well, so you can't update them individually. Eventually, the only way to install even non-native apps is to update the whole macOS.

This is what you sign up for when you buy an Apple product. Apple has mastered the art of tempting you without letting you realize what's really going on until it's too late. Apple was, is, and always will be evil. The clue is in their logo.

Maybe stop using the mickey mouse browsers? I mean Firefox is pretty much a lost cause.. unless you start using extensions. I agree those are basic features that should be built-in. In qutebrowser I use them reliably all the time. E.g press T (keybinding for :tab-focus command) - type keyword (matches against tab ID, page title, page URL & the tab's process ID) - press Tab - menu is populated with results - cycle through them using Tab/Shift+Tab - press Enter to jump to it. Similar workflow for history, different bookmark types, etc. History can also be loaded as an HTML page and jumped through with regex, etc. If you want to stick with

There is. By default it tries to obey your query. But if that query returns no results, only then it makes a best-effort attempt to return something vaguely related.

You don't really realize how Apple rips the soul out of your chest for a profit, until it's too late. Good luck with that.

> many, many overly redundant internets that are "Great Firewalled" from one another

This actually has name, "the dark forest theory of the internet".

I've personally reverted back to many offline/analog sources of information and community participation.

Yeah, same. I realized for the most part, using the internet isn't worth it anymore. I was using it out of inertia and thinking it offered convenience. Realistically, that convenience isn't there anymore. As others mentioned, I also started reading a lot more books, I meet with people, I always phone call instead of messaging, I also attend talks (local universities are great) and go to museums, etc.

Captcha passing services cost peanuts btw. Some also offer a browser extension that automates the API call.

I've posted several reviews recently on Google, rating the company 1 star and warning that they're customer support is using AI agents that are unhelpful and try to waste your time. The other crazy thing is restaurants who use AI generated pictures in their marketing. Instant yuck.

How exactly do they obtain this data? Residential proxy providers don't publish their IP list (you connect to one of their servers which then tunnels your traffic to the residential exit point). Plus there are tons of such providers.

In any case, residential proxies are a godsend. Because most of the everyday services like web shops, govt information portals, even personal blogs sometimes are blocking access usings captchas.

EDIT: they write this on their marketing copy [0]:

> The Spur platform identifies traffic originating from residential proxy networks by analyzing service fingerprints, ASN ownership, and behavioral indicators.

Sounds like guesswork that results in a ton of false positives. And the more innocent IPs are blocked by platforms on the basis of this data, the more the demand increases for residential proxies, from users who need access to essential services. Talk of creating the problem and then selling the "solution".

[0] https://spur.us/platform/residential-proxy-detection